Sustained-Release Progesterone Vaginal Suppositories 2-Development and Quality Testing-
نویسندگان
چکیده
منابع مشابه
Indomethacin sustained-release suppositories containing sugar ester.
We prepared indomethacin (IM) sustained-release suppositories using sugar ester (SE) as an additive. The suppositories were prepared by the fusion method with IM, SE, and Witepsol H-15 (H-15) and their availabilities in vitro and in vivo were evaluated mainly by the drug release test and the absorption test in rabbits, respectively. The softening point of the suppositories increased with increa...
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Microbicides are an active area of research for HIV prevention, being developed as a woman-initiated method of prevention during unprotected coitus. Along with safety and efficacy, assessing and improving compliance is a major area of research in microbicide development. We have produced microbicide prototypes in the form of semisoft vaginal suppositories prepared from carrageenan and conducted...
متن کاملApplication of nifedipine sustained-release suppositories to healthy volunteers.
poorly water-soluble-carrier, were administered to healthy volunteers, and their sustained-release characteristics, bioavailability and clinical utility were investigated. It was found that D-15 was able to maintain a therapeutically effective level of NF from 30 min to 10 h without causing an excessively high peak level and offered good bioavailability. From the results of pharmacokinetic anal...
متن کاملFabrication of a Reservoir Ring for Sustained and Prolonged Release of Levonorgestrel for Vaginal Administration
Introduction: More than one-third of women experience abnormal uterine bleeding (AUB) during their lifetime. One of the treatment methods of this disease is hormone therapy. Vaginal rings (VRs) containing progesterone hormones could be a good choice for treatment. In this study, the design and construction of a reservoir ring with the ability to release levonorgestrel hormone has been investiga...
متن کاملFormulation Development and Release Studies of Indomethacin Suppositories
Indomethacin suppositories were prepared by using water-soluble and oil soluble suppository bases, and evaluated for in vitro release by USP I and modified continuous flow through bead bed apparatus. Effect of the Tween 80 (1% and 5%) was further studied on in vitro release of the medicament. Release rate was good in water-soluble suppositories bases in comparison to oil soluble suppositories b...
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ژورنال
عنوان ژورنال: Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
سال: 2009
ISSN: 1882-1499,1346-342X
DOI: 10.5649/jjphcs.35.343